InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Skor2

Summary

InnateDB Protein

IDBP-623828.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Skor2

Protein Name

SKI family transcriptional corepressor 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132338

InnateDB Gene

IDBG-606029 (Skor2)

Protein Structure

UniProt Annotation

Function

Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity. {ECO:0000250, ECO:0000269PubMed:18522874}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:18522874}. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is restricted to adult and embryonic central nervous system. Expressed at high levels in the developing cerebellum, ventral metencephalon and myelencephalon at E12.5 (at protein level). In the adult cerebellum, expressed specifically in Purkinje cells. {ECO:0000269PubMed:18522874}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0042826	histone deacetylase binding
GO:0046332	SMAD binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0021587	cerebellum morphogenesis
GO:0021702	cerebellar Purkinje cell differentiation
GO:0021936	regulation of cerebellar granule cell precursor proliferation
GO:0030514	negative regulation of BMP signaling pathway
GO:0045880	positive regulation of smoothened signaling pathway
GO:0048814	regulation of dendrite morphogenesis