Version 5.4
Mus musculus Protein: Anp32e
Summary
InnateDB Protein IDBP-623836.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Anp32e
Protein Name acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Synonyms 2810018A15Rik; AI047746; AI326868; CPD1; LANP-L; LANPL; mLANP-L;
Species Mus musculus
Ensembl Protein ENSMUSP00000128483
InnateDB Gene IDBG-174201 (Anp32e)
Protein Structure
UniProt Annotation
Function Histone chaperone that specifically mediates the genome- wide removal of histone H2A.Z/H2AFZ from the nucleosome: removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state (PubMed:24463511). Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis. {ECO:0000269PubMed:11430900, ECO:0000269PubMed:14964690, ECO:0000269PubMed:16420440, ECO:0000269PubMed:24463511}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Expressed at highest levels in cerebellum and spleen. In the cerebellum, expressed mainly in granule cells and, to a lesser extent, in Purkinje cells. {ECO:0000269PubMed:11430900}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019212 phosphatase inhibitor activity
GO:0042393 histone binding
Biological Process
GO:0043086 negative regulation of catalytic activity
GO:0043486 histone exchange
Cellular Component
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016023 cytoplasmic membrane-bounded vesicle
Protein Structure and Domains
PDB ID MGI:1913721
InterPro IPR001611 Leucine-rich repeat
PFAM PF00560
PF13504
PF13855
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97822
PhosphoSite PhosphoSite-P97822
TrEMBL E9Q5H2
UniProt Splice Variant
Entrez Gene 66471
UniGene Mm.474096
RefSeq NP_075699
MGI ID
MGI Symbol Anp32e
OMIM
CCDS CCDS17626
HPRD
IMGT
EMBL AB037685 AC092855 AK012759 AK049647 AK076049 AK088401 AK147888 AK168380 BC005690 BC080684 U89345
GenPept AAB49462 AAH05690 AAH80684 BAB03507 BAB28449 BAC33858 BAC36147 BAC40331 BAE28205 BAE40309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca