InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cys1

Summary

InnateDB Protein

IDBP-623904.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cys1

Protein Name

cystin 1

Synonyms

2900006B19Rik; AV218859; Ccap; ck; cpk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133902

InnateDB Gene

IDBG-131167 (Cys1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cell projection, cilium membrane; Lipid- anchor. Cytoplasm, cytoskeleton, cilium axoneme. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus (By similarity). Expression is enriched in the ciliary axoneme. {ECO:0000250}.

Disease Associations

Note=Defects in Cys1 are a cause of polycystic kidney disease. {ECO:0000269PubMed:11854326}.

Tissue Specificity

Expressed primarily in the kidney and liver. Expressed at lower levels in the lung, brain and heart. {ECO:0000269PubMed:11854326}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0001822	kidney development
GO:0048839	inner ear development

Cellular Component

GO:0005930	axoneme
GO:0036064	ciliary basal body
GO:0045121	membrane raft
GO:0060170	ciliary membrane

Protein Structure and Domains

PDB ID

MGI:2177632

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R4T1

PhosphoSite

PhosphoSite-Q8R4T1

TrEMBL

UniProt Splice Variant

Entrez Gene

12879

UniGene

Mm.52265

RefSeq

XP_006515014

MGI ID

MGI Symbol

Cys1

OMIM

CCDS

CCDS36422

HPRD

IMGT

EMBL

AF390547 AF390548 BC139298 BC139302 BC145598 BC171971

GenPept

AAI39299 AAI39303 AAI45599 AAI71971 AAM08225 AAM08707