InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wnt10b

Summary

InnateDB Protein

IDBP-623928.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt10b

Protein Name

wingless related MMTV integration site 10b

Synonyms

Wnt12;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131056

InnateDB Gene

IDBG-181195 (Wnt10b)

Protein Structure

UniProt Annotation

Function

Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Expressed in embryos and in the mammary gland of non-pregnant mice.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002062	chondrocyte differentiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006629	lipid metabolic process
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0007224	smoothened signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0014835	myoblast differentiation involved in skeletal muscle regeneration
GO:0016055	Wnt signaling pathway
GO:0030182	neuron differentiation
GO:0030501	positive regulation of bone mineralization
GO:0030858	positive regulation of epithelial cell differentiation
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043403	skeletal muscle tissue regeneration
GO:0045165	cell fate commitment
GO:0045598	regulation of fat cell differentiation
GO:0045599	negative regulation of fat cell differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045778	positive regulation of ossification
GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048641	regulation of skeletal muscle tissue development
GO:0048741	skeletal muscle fiber development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050821	protein stabilization
GO:0050909	sensory perception of taste
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051246	regulation of protein metabolic process
GO:0051885	positive regulation of anagen
GO:0060070	canonical Wnt signaling pathway
GO:0060346	bone trabecula formation
GO:0061196	fungiform papilla development
GO:0071310	cellular response to organic substance
GO:0071320	cellular response to cAMP
GO:0071374	cellular response to parathyroid hormone stimulus
GO:0071407	cellular response to organic cyclic compound
GO:0071425	hematopoietic stem cell proliferation
GO:0071464	cellular response to hydrostatic pressure
GO:0090263	positive regulation of canonical Wnt signaling pathway