Version 5.4
Mus musculus Protein: Aim2
Summary
InnateDB Protein IDBP-623929.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aim2
Protein Name absent in melanoma 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000134329
InnateDB Gene IDBG-205873 (Aim2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0002218 activation of innate immune response
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032461 positive regulation of protein oligomerization
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0035458 cellular response to interferon-beta
GO:0035690 cellular response to drug
GO:0045087 innate immune response (InnateDB)
GO:0050702 interleukin-1 beta secretion
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070269 pyroptosis
GO:2001056 positive regulation of cysteine-type endopeptidase activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0097169 AIM2 inflammasome complex
Protein Structure and Domains
PDB ID MGI:2686159
InterPro IPR004020 DAPIN domain
IPR011029 Death-like domain
PFAM PF02758
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL G3UZ36
UniProt Splice Variant
Entrez Gene 383619
UniGene Mm.420404
RefSeq
MGI ID
MGI Symbol Aim2
OMIM
CCDS
HPRD
IMGT
EMBL AC084073 AC087781
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca