InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mvp

Summary

InnateDB Protein

IDBP-623952.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mvp

Protein Name

major vault protein

Synonyms

2310009M24Rik; LRP; VAULT1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127250

InnateDB Gene

IDBG-209997 (Mvp)

Protein Structure

UniProt Annotation

Function

Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0008283	cell proliferation
GO:0023057	negative regulation of signaling
GO:0031953	negative regulation of protein autophosphorylation
GO:0038127	ERBB signaling pathway
GO:0061099	negative regulation of protein tyrosine kinase activity
GO:0072376	protein activation cascade

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome