InnateDB Protein
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IDBP-6240.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TST
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Protein Name
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thiosulfate sulfurtransferase (rhodanese)
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Synonyms
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RDS;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000249042
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InnateDB Gene
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IDBG-6238 (TST)
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Protein Structure
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Function |
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA. {ECO:0000250, ECO:0000269PubMed:20663881, ECO:0000269PubMed:21685364}.
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Subcellular Localization |
Mitochondrion matrix.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001763
Rhodanese-like domain
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PFAM |
PF00581
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PRINTS |
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PIRSF |
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SMART |
SM00450
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TIGRFAMs |
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Modification |
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SwissProt |
Q16762
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PhosphoSite |
PhosphoSite-Q16762
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TrEMBL |
B1AH48
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UniProt Splice Variant |
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Entrez Gene |
7263
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UniGene |
Hs.474783
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RefSeq |
NP_003303
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HUGO |
HGNC:12388
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OMIM |
180370
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CCDS |
CCDS13938
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HPRD |
01583
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IMGT |
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EMBL |
AK091874
BC010148
CH471095
CR456598
CR456998
D87292
Z73420
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GenPept |
AAH10148
BAA13327
BAG52433
CAA97762
CAG30484
CAG33279
EAW60132
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