InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Khdc3

Summary

InnateDB Protein

IDBP-624001.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Khdc3

Protein Name

RIKEN cDNA 2410004A20 gene

Synonyms

2410004A20Rik; AI467128; FILIA; OEEP48;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133915

InnateDB Gene

IDBG-606057 (Khdc3)

Protein Structure

UniProt Annotation

Function

Required for maintenance of euploidy during cleavage- stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function. Capable of binding RNA. {ECO:0000269PubMed:19376971, ECO:0000269PubMed:22276159}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000269PubMed:18057100, ECO:0000269PubMed:18804437}. Note=Located throughout the cell cortex of ovulated eggs in a complex with NLRP5. After fertilization, restricted to the apical cortex and excluded from regions of cell-cell contact. {ECO:0000269PubMed:18057100}.

Disease Associations

Tissue Specificity

Detected in ovary, but not in testis or somatic tissues. In the ovary, expressed in growing oocytes. {ECO:0000269PubMed:18057100}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007094	mitotic spindle assembly checkpoint
GO:0007275	multicellular organismal development
GO:0090307	spindle assembly involved in mitosis