InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc14a2

Summary

InnateDB Protein

IDBP-624019.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc14a2

Protein Name

solute carrier family 14 (urea transporter), member 2

Synonyms

UT-A1; UT-A3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126416

InnateDB Gene

IDBG-160719 (Slc14a2)

Protein Structure

UniProt Annotation

Function

Specialized low-affinity vasopressin-regulated urea transporter. Mediates rapid transepithelial urea transport across the inner medullary collecting duct and plays a major role in the urinary concentrating mechanism. Vasopressin regulates urea transport by increasing isoform A1 accumulation in the plasma membrane and/or phosphorylation of isoform A1 (By similarity). {ECO:0000250}.

Subcellular Localization

Apical cell membrane {ECO:0000250}; Multi- pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in kidney medulla. Also detected at the protein level in testes, heart, brain and liver. In the kidney, present in thin descending limbs of the loop of Henle and in the middle and terminal inner medullary collecting ducts. Isoform A5 is expressed in the peritubular myoid cells forming the outermost layer of the seminiferous tubules within the testes and is not detected in kidney. Isoform A5 mRNA levels are coordinated with the stage of testes development and increase 15 days postpartum, commensurate with the start of seminiferous tubule fluid movement. {ECO:0000269PubMed:12217874}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015204	urea transmembrane transporter activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0071918

urea transmembrane transport

Cellular Component

GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane

Protein Structure and Domains

PDB ID

MGI:1351653

InterPro

IPR004937 Urea transporter

PFAM

PF03253

PRINTS

PIRSF

PIRSF016502

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R4T9

PhosphoSite

PhosphoSite-Q8R4T9

TrEMBL

UniProt Splice Variant

Entrez Gene

27411

UniGene

Mm.44158

RefSeq

NP_001103744

MGI ID

MGI Symbol

Slc14a2

OMIM

CCDS

CCDS50331

HPRD

IMGT

EMBL

AF258601 AF258602 AF366052 AF367359 BC150680 CH466528

GenPept

AAG32167 AAG32168 AAI50681 AAM00357 AAM21206 EDL09434