InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GMPS

Summary

InnateDB Protein

IDBP-62409.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GMPS

Protein Name

guanine monphosphate synthetase

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000295920

InnateDB Gene

IDBG-62407 (GMPS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	34 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003921	GMP synthase activity
GO:0003922	GMP synthase (glutamine-hydrolyzing) activity
GO:0004066	asparagine synthase (glutamine-hydrolyzing) activity
GO:0005524	ATP binding
GO:0016462	pyrophosphatase activity
GO:0016740	transferase activity
GO:0016787	hydrolase activity

Biological Process

GO:0006144	purine nucleobase metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0006529	asparagine biosynthetic process
GO:0006541	glutamine metabolic process
GO:0008033	tRNA processing
GO:0009113	purine nucleobase biosynthetic process
GO:0009168	purine ribonucleoside monophosphate biosynthetic process
GO:0044281	small molecule metabolic process
GO:0055086	nucleobase-containing small molecule metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001674 GMP synthase, C-terminal
IPR001962 Asparagine synthase
IPR004506 tRNA-specific 2-thiouridylase
IPR011697 Peptidase C26
IPR017926 Glutamine amidotransferase
IPR018317 Queuosine biosynthesis protein QueC
IPR022310 NAD/GMP synthase
IPR029062 Class I glutamine amidotransferase-like

PFAM