InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arpp19

Summary

InnateDB Protein

IDBP-624122.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arpp19

Protein Name

cAMP-regulated phosphoprotein 19

Synonyms

19kDa; 2700024H10Rik; ARPP-19; Arpp12; AW559096;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126618

InnateDB Gene

IDBG-184720 (Arpp19)

Protein Structure

UniProt Annotation

Function

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0005102	receptor binding
GO:0008601	protein phosphatase type 2A regulator activity
GO:0015459	potassium channel regulator activity
GO:0019212	phosphatase inhibitor activity
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0043086	negative regulation of catalytic activity
GO:0045722	positive regulation of gluconeogenesis
GO:0050790	regulation of catalytic activity