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InnateDB Protein
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IDBP-624132.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Arpp19
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Protein Name
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cAMP-regulated phosphoprotein 19
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Synonyms
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19kDa; 2700024H10Rik; ARPP-19; Arpp12; AW559096;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000131597
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InnateDB Gene
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IDBG-184720 (Arpp19)
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Protein Structure
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| Function |
Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression by binding to the NGF-regulatory region of its mRNA (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
4 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1891691
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| InterPro |
IPR006760
Endosulphine
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| PFAM |
PF04667
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-P56212
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| TrEMBL |
E9PXD7
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| UniProt Splice Variant |
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| Entrez Gene |
59046
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| UniGene |
Mm.473473
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Arpp19
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
CT033761
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| GenPept |
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Version 5.4