Version 5.4
Mus musculus Protein: Fam3c
Summary
InnateDB Protein IDBP-624146.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam3c
Protein Name family with sequence similarity 3, member C
Synonyms D6Wsu176e; Ilei;
Species Mus musculus
Ensembl Protein ENSMUSP00000127709
InnateDB Gene IDBG-129573 (Fam3c)
Protein Structure
UniProt Annotation
Function May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition. {ECO:0000269PubMed:16959614, ECO:0000269PubMed:19015638, ECO:0000269PubMed:20059962}.
Subcellular Localization Secreted {ECO:0000269PubMed:20059962}. Cytoplasmic vesicle {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level). {ECO:0000269PubMed:15194199, ECO:0000269PubMed:16959614, ECO:0000269PubMed:20059962}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007275 multicellular organismal development
GO:0008150 biological_process
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:107892
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91VU0
PhosphoSite PhosphoSite-
TrEMBL G3X9I1
UniProt Splice Variant
Entrez Gene 27999
UniGene Mm.485232
RefSeq NP_613053
MGI ID
MGI Symbol Fam3c
OMIM
CCDS CCDS39436
HPRD
IMGT
EMBL AC115039 AK004059 AK154498 AK170887 AY424275 BC009086 BC055853 CH466533
GenPept AAH09086 AAH55853 AAR84605 BAB23146 BAE32629 BAE42094 EDL13839 EDL13845

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca