InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: P4ha2

Summary

InnateDB Protein

IDBP-624218.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P4ha2

Protein Name

procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha II polypeptide

Synonyms

AA407196; C76437; P4hl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133275

InnateDB Gene

IDBG-172623 (P4ha2)

Protein Structure

UniProt Annotation

Function

Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.

Subcellular Localization

Endoplasmic reticulum lumen.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004656	procollagen-proline 4-dioxygenase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016702	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418	L-ascorbic acid binding

Biological Process

GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0016222	procollagen-proline 4-dioxygenase complex

Protein Structure and Domains

PDB ID

MGI:894286

InterPro

IPR005123 Oxoglutarate/iron-dependent dioxygenase
IPR006620 Prolyl 4-hydroxylase, alpha subunit
IPR013026 Tetratricopeptide repeat-containing domain
IPR013547 Prolyl 4-hydroxylase alpha-subunit, N-terminal
IPR019734 Tetratricopeptide repeat

PFAM

PF03171
PF13640
PF08336
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00702
SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60716