InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atxn10

Summary

InnateDB Protein

IDBP-624256.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atxn10

Protein Name

ataxin 10

Synonyms

AI325283; C77170; E46; Sca10; TEG-169; Tex169;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132450

InnateDB Gene

IDBG-170543 (Atxn10)

Protein Structure

UniProt Annotation

Function

Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}.

Disease Associations

Tissue Specificity

In high cell density areas; cerebellar cortex, dentate gyrus, hippocampus, anterior olfactory nucleus, primary olfactory cortex. {ECO:0000269PubMed:15201271}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005488	binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0007399	nervous system development
GO:0008150	biological_process
GO:0031175	neuron projection development

Cellular Component

GO:0005575	cellular_component
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0048471	perinuclear region of cytoplasm