InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptprj

Summary

InnateDB Protein

IDBP-624365.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptprj

Protein Name

protein tyrosine phosphatase, receptor type, J

Synonyms

AI450271; BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2; RPTPJ; Scc-1; Scc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129592

InnateDB Gene

IDBG-189428 (Ptprj)

Protein Structure

UniProt Annotation

Function

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET, KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. May be involved in the mechanism of contact inhibition of cell growth. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling. {ECO:0000269PubMed:12588999, ECO:0000269PubMed:12771128, ECO:0000269PubMed:12833140, ECO:0000269PubMed:12913111, ECO:0000269PubMed:18249142, ECO:0000269PubMed:19246339, ECO:0000269PubMed:19268662}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Cell projection, ruffle membrane. Cell junction. Note=After T-cell stimulation, it is temporarily excluded from immunological synapses. Found at cell borders.

Disease Associations

Tissue Specificity

Expressed at high levels in brain, kidney, spleen and intestine, and at lower levels in liver, lung, thymus and heart. Expressed at a high level in the myeloid cell line FDC- P2, and at a lower level in the pre-B lymphoid cell line WEHI-231 and the T hybridoma cell line HB21.7.31. Not expressed in the fibroblast cell line NIH3T3 or the erythroid cell line F5-5. Expressed in macrophages. {ECO:0000269PubMed:8483328, ECO:0000269PubMed:8549806, ECO:0000269PubMed:9823776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0016791	phosphatase activity
GO:0045295	gamma-catenin binding
GO:0051019	mitogen-activated protein kinase binding
GO:0070097	delta-catenin binding

Biological Process

GO:0001570	vasculogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006470	protein dephosphorylation
GO:0007507	heart development
GO:0007596	blood coagulation
GO:0008285	negative regulation of cell proliferation
GO:0010572	positive regulation of platelet activation
GO:0010642	negative regulation of platelet-derived growth factor receptor signaling pathway
GO:0010759	positive regulation of macrophage chemotaxis
GO:0016311	dephosphorylation
GO:0030308	negative regulation of cell growth
GO:0030336	negative regulation of cell migration
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043116	negative regulation of vascular permeability
GO:0043407	negative regulation of MAP kinase activity
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048709	oligodendrocyte differentiation
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0051894	positive regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0051898	negative regulation of protein kinase B signaling
GO:2000272	negative regulation of receptor activity

Cellular Component

GO:0001772	immunological synapse
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

MGI:104574

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00041
PF01108

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt