InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Filip1l

Summary

InnateDB Protein

IDBP-624371.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Filip1l

Protein Name

filamin A interacting protein 1-like

Synonyms

4631422O05Rik; Doc1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133252

InnateDB Gene

IDBG-168797 (Filip1l)

Protein Structure

UniProt Annotation

Function

Acts as a regulator of the antiangiogenic activity on endothelial cells. When overexpressed in endothelial cells, leads to inhibition of cell proliferation and migration and an increase in apoptosis. Inhibits melanoma growth When expressed in tumor- associated vasculature (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005575	cellular_component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1925999

InterPro

IPR009053 Prefoldin
IPR019131 Cortactin-binding protein-2, N-terminal

PFAM

PF09727

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P6L0

PhosphoSite

PhosphoSite-Q6P6L0

TrEMBL

UniProt Splice Variant

Entrez Gene

78749

UniGene

Mm.328360

RefSeq

MGI ID

MGI Symbol

Filip1l

OMIM

CCDS

HPRD

IMGT

EMBL

AK146705 BC024523 BC062166 BC098507 EU623548 EU704258

GenPept

AAH24523 AAH62166 AAH98507 ACC91883 ACD92726 BAE27371