Version 5.4
| Mus musculus Protein: Hbp1 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-624456.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Hbp1 | ||||||||
| Protein Name | high mobility group box transcription factor 1 | ||||||||
| Synonyms | 1700058O05Rik; BE629963; C330012F01Rik; C86454; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000131158 | ||||||||
| InnateDB Gene | IDBG-133685 (Hbp1) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Nucleus {ECO:0000255PROSITE- ProRule:PRU00267, ECO:0000269PubMed:15235594}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:894659 | ||||||||
| InterPro |
IPR003652
Ataxin, AXH domain IPR009071 High mobility group box domain IPR013723 Ataxin-1/HBP1 module (AXH) |
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| PFAM |
PF00505
PF09011 PF08517 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00536
SM00398 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8R316 | ||||||||
| PhosphoSite | PhosphoSite-Q8R316 | ||||||||
| TrEMBL | Q3UTR1 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 73389 | ||||||||
| UniGene | Mm.411103 | ||||||||
| RefSeq | NP_694878 | ||||||||
| MGI ID | 1V06 | ||||||||
| MGI Symbol | Hbp1 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS25867 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK028674 AK082770 AK133127 AK139211 AK142187 BC026853 CT010463 | ||||||||
| GenPept | AAH26853 BAC26060 BAC38611 BAE21520 BAE23919 BAE24968 | ||||||||