Version 5.4
Mus musculus Protein: Arf5
Summary
InnateDB Protein IDBP-624522.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arf5
Protein Name ADP-ribosylation factor 5
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000127281
InnateDB Gene IDBG-130550 (Arf5)
Protein Structure
UniProt Annotation
Function GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.
Subcellular Localization Golgi apparatus. Cytoplasm, perinuclear region {ECO:0000250}.
Disease Associations
Tissue Specificity Ubiquitous.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:99434
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00503
PF00071
PF00025
PF04670
PF08477
PF09439
PRINTS PR00318
PR00449
PR00328
PIRSF
SMART SM00275
SM00175
SM00178
SM00177
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P84084
PhosphoSite PhosphoSite-P84084
TrEMBL
UniProt Splice Variant
Entrez Gene 11844
UniGene
RefSeq
MGI ID
MGI Symbol Arf5
OMIM
CCDS CCDS19952
HPRD
IMGT
EMBL BC132452 BC138756 D87902
GenPept AAI32453 AAI38757 BAA13494

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca