InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shisa9

Summary

InnateDB Protein

IDBP-624913.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shisa9

Protein Name

shisa homolog 9 (Xenopus laevis)

Synonyms

2700045P11Rik; Ckamp44;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132646

InnateDB Gene

IDBG-133592 (Shisa9)

Protein Structure

UniProt Annotation

Function

Regulator of short-term neuronal synaptic plasticity in the dentate gyrus. Associates with AMPA receptors (ionotropic glutamate receptors) in synaptic spines and promotes AMPA receptor desensitization at excitatory synapses. {ECO:0000269PubMed:20185686}.

Subcellular Localization

Cell projection, dendritic spine membrane {ECO:0000269PubMed:20185686}; Single-pass type I membrane protein {ECO:0000269PubMed:20185686}. Cell junction, synapse {ECO:0000269PubMed:20185686}.

Disease Associations

Tissue Specificity

Brain-specific. Mainly expressed in neurons, including in hippocampus, cerebral cortex, striatum, thalamus, olfactory bulb and cerebellum. Expressed in most brain structures during embryonic and postnatal development. {ECO:0000269PubMed:20185686}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0048172

regulation of short-term neuronal synaptic plasticity

Cellular Component

GO:0008328	ionotropic glutamate receptor complex
GO:0030054	cell junction
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
GO:0032591	dendritic spine membrane
GO:0045202	synapse