InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBX2

Summary

InnateDB Protein

IDBP-62494.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBX2

Protein Name

T-box 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000240328

InnateDB Gene

IDBG-62492 (TBX2)

Protein Structure

UniProt Annotation

Function

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence. May be required for cardiac atrioventricular canal formation. {ECO:0000269PubMed:22002537}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00201}.

Disease Associations

Tissue Specificity

Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0003007	heart morphogenesis
GO:0003148	outflow tract septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003203	endocardial cushion morphogenesis
GO:0003256	regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007521	muscle cell fate determination
GO:0007569	cell aging
GO:0008284	positive regulation of cell proliferation
GO:0035909	aorta morphogenesis
GO:0036302	atrioventricular canal development
GO:0042733	embryonic digit morphogenesis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048738	cardiac muscle tissue development
GO:0060021	palate development
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060465	pharynx development
GO:0060560	developmental growth involved in morphogenesis
GO:0060596	mammary placode formation
GO:0090398	cellular senescence
GO:1901208	negative regulation of heart looping
GO:1901211	negative regulation of cardiac chamber formation

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

InterPro

IPR001699 Transcription factor, T-box
IPR002070 Transcription factor, Brachyury
IPR008967 p53-like transcription factor, DNA-binding
IPR022582 Transcription factor, T-box, region of unknown function

PFAM

PF00907
PF12598

PRINTS

PR00937
PR00938

PIRSF

SMART

SM00425

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt