InnateDB Protein
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IDBP-624992.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Elovl1
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Protein Name
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elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
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Synonyms
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AA407424; BB151133; Ssc1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000126685
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InnateDB Gene
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IDBG-181447 (Elovl1)
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Protein Structure
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Function |
Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. {ECO:0000269PubMed:10791983, ECO:0000269PubMed:23407971}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in a broad variety of tissues. Highly expressed in stomach, lung, kidney, skin and intestine. Moderately expressed in white adipose tissue, liver, spleen, brain, brown adipose tissue, heart and muscle. Weakly expressed in testis. {ECO:0000269PubMed:10791983}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
Accession |
GO Term |
GO:0009922
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fatty acid elongase activity
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Biological Process |
GO:0019367
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fatty acid elongation, saturated fatty acid
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GO:0030148
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sphingolipid biosynthetic process
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GO:0034625
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fatty acid elongation, monounsaturated fatty acid
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GO:0042761
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very long-chain fatty acid biosynthetic process
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Cellular Component |
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PDB ID |
MGI:1858959
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InterPro |
IPR002076
GNS1/SUR4 membrane protein
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PFAM |
PF01151
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9JLJ5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q548M4
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UniProt Splice Variant |
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Entrez Gene |
54325
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UniGene |
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RefSeq |
XP_006503296
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MGI ID |
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MGI Symbol |
Elovl1
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OMIM |
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CCDS |
CCDS18549
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HPRD |
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IMGT |
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EMBL |
AF170907
AF322919
AK003743
AK135348
AK156003
AK171217
BC006735
CH466552
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GenPept |
AAF72572
AAH06735
AAL73137
BAB22975
BAE22497
BAE33541
BAE42321
EDL30504
EDL30505
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