Version 5.4
Mus musculus Protein: Ppard
Summary
InnateDB Protein IDBP-625020.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppard
Protein Name peroxisome proliferator activator receptor delta
Synonyms Nr1c2; NUC-1; NUC1; PPAR-beta; PPAR-delta; PPAR[b]; Pparb; Pparb/d; PPARdelta;
Species Mus musculus
Ensembl Protein ENSMUSP00000133077
InnateDB Gene IDBG-158082 (Ppard)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0008144 drug binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0051059 NF-kappaB binding
GO:0070539 linoleic acid binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001890 placenta development
GO:0006029 proteoglycan metabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0006629 lipid metabolic process
GO:0006776 vitamin A metabolic process
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008366 axon ensheathment
GO:0008544 epidermis development
GO:0008654 phospholipid biosynthetic process
GO:0009299 mRNA transcription
GO:0009749 response to glucose
GO:0009987 cellular process
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014823 response to activity
GO:0014912 negative regulation of smooth muscle cell migration
GO:0019395 fatty acid oxidation
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030522 intracellular receptor signaling pathway
GO:0031589 cell-substrate adhesion
GO:0032024 positive regulation of insulin secretion
GO:0032966 negative regulation of collagen biosynthetic process
GO:0033189 response to vitamin A
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0042640 anagen
GO:0043066 negative regulation of apoptotic process
GO:0043401 steroid hormone mediated signaling pathway
GO:0043616 keratinocyte proliferation
GO:0045598 regulation of fat cell differentiation
GO:0045684 positive regulation of epidermis development
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045909 positive regulation of vasodilation
GO:0046697 decidualization
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0051546 keratinocyte migration
GO:0060612 adipose tissue development
GO:0071456 cellular response to hypoxia
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:101884
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
IPR003074 Peroxisome proliferator-activated receptor
IPR003075 Peroxisome proliferator-activated receptor, beta
IPR008946 Nuclear hormone receptor, ligand-binding
PFAM PF00105
PRINTS PR00047
PR01288
PR01290
PIRSF
SMART SM00399
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PV57
UniProt Splice Variant
Entrez Gene 19015
UniGene Mm.486938
RefSeq
MGI ID
MGI Symbol Ppard
OMIM
CCDS
HPRD
IMGT
EMBL AC126937 CT025652
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca