Version 5.4
Mus musculus Protein: Phf6
Summary
InnateDB Protein IDBP-625027.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Phf6
Protein Name PHD finger protein 6
Synonyms 2700007B13Rik; 4931428F02Rik; mKIAA1823;
Species Mus musculus
Ensembl Protein ENSMUSP00000130358
InnateDB Gene IDBG-145356 (Phf6)
Protein Structure
UniProt Annotation
Function Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Nuclear, it particularly localizes to the nucleolus. {ECO:0000250}.
Disease Associations
Tissue Specificity At 12.5 dpc it is highly expressed in the embryonic central nervous system and at lower levels in other tissues. Very low levels present throughout the adult brain. {ECO:0000269PubMed:12415272}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID MGI:1918248
InterPro IPR001965 Zinc finger, PHD-type
IPR011011 Zinc finger, FYVE/PHD-type
PFAM
PRINTS
PIRSF
SMART SM00249
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D4J7
PhosphoSite PhosphoSite-Q9D4J7
TrEMBL Q3UXP1
UniProt Splice Variant
Entrez Gene 70998
UniGene Mm.404935
RefSeq NP_001277475
MGI ID
MGI Symbol Phf6
OMIM
CCDS CCDS72380
HPRD
IMGT
EMBL AK016480 AK028498 AK038320 AK122560 AK135407 BC043127 BC055330 BC057374
GenPept AAH43127 AAH55330 AAH57374 BAB30260 BAC25980 BAC29968 BAC65842 BAE22522

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca