InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plec

Summary

InnateDB Protein

IDBP-625114.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plec

Protein Name

plectin

Synonyms

AA591047; AU042537; EBS1; PCN; Plec1; PLTN;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127867

InnateDB Gene

IDBG-153069 (Plec)

Protein Structure

UniProt Annotation

Function

Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell junction, hemidesmosome {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in lung, brain, small intestine, muscle, heart and skin with lower levels found in kidney, liver, uterus, spleen and salivary gland. {ECO:0000269PubMed:10556294}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	18 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0030506	ankyrin binding

Biological Process

GO:0031581	hemidesmosome assembly
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005856	cytoskeleton
GO:0005925	focal adhesion
GO:0030056	hemidesmosome
GO:0042383	sarcolemma
GO:0043292	contractile fiber
GO:0045111	intermediate filament cytoskeleton