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InnateDB Protein
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IDBP-625121.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Plec
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Protein Name
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plectin
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Synonyms
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AA591047; AU042537; EBS1; PCN; Plec1; PLTN;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000131946
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InnateDB Gene
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IDBG-153069 (Plec)
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Protein Structure
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| Function |
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. May be involved not only in the cross-linking and stabilization of cytoskeletal intermediate filaments network, but also in the regulation of their dynamics.
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| Subcellular Localization |
Cytoplasm, cytoskeleton. Cell junction, hemidesmosome {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Expressed at high levels in lung, brain, small intestine, muscle, heart and skin with lower levels found in kidney, liver, uterus, spleen and salivary gland. {ECO:0000269PubMed:10556294}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
19
[view]
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| Protein-Protein |
18
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
44 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:1277961
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| InterPro |
IPR001715
Calponin homology domain
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| PFAM |
PF00307
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| PRINTS |
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| PIRSF |
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| SMART |
SM00033
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9QXS1
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
18810
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| UniGene |
Mm.418021
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Plec
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4