InnateDB Protein
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IDBP-625290.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nrg4
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Protein Name
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neuregulin 4
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Synonyms
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AI552600;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000130929
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InnateDB Gene
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IDBG-167795 (Nrg4)
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Protein Structure
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Function |
Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. {ECO:0000269PubMed:10348342}.
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Subcellular Localization |
Pro-neuregulin-4, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.Neuregulin-4: Secreted {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in pancreas; weakly expressed in muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1933833
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InterPro |
IPR000742
Epidermal growth factor-like domain
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PFAM |
PF00008
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PRINTS |
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PIRSF |
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SMART |
SM00181
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WTX4
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PhosphoSite |
PhosphoSite-
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TrEMBL |
D3Z0G2
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UniProt Splice Variant |
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Entrez Gene |
83961
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UniGene |
Mm.466946
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RefSeq |
NP_114391
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MGI ID |
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MGI Symbol |
Nrg4
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OMIM |
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CCDS |
CCDS52801
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HPRD |
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IMGT |
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EMBL |
AC157328
AF083067
CT025532
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GenPept |
AAD21874
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