InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slitrk2

Summary

InnateDB Protein

IDBP-625326.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slitrk2

Protein Name

SLIT and NTRK-like family, member 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130057

InnateDB Gene

IDBG-149204 (Slitrk2)

Protein Structure

UniProt Annotation

Function

Suppresses neurite outgrowth. {ECO:0000269PubMed:14550773}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

In the adult, significant expression is detected only in the brain. Broadly expressed in embryonic brain with highest expression in ventricular layer, subventricular zone, cortical plate, pyramidal layer of hippocampus, subicular neuroepithelium, thalamus, hypothalumus and spinal cord. {ECO:0000269PubMed:14550773}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0007409

axonogenesis

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2679449

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01462
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00013
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q810C0