InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RANBP9

Summary

InnateDB Protein

IDBP-62536.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RANBP9

Protein Name

RAN binding protein 9

Synonyms

BPM-L; BPM90; RanBP7; RANBPM;

Species

Homo sapiens

Ensembl Protein

ENSP00000011619

InnateDB Gene

IDBG-62534 (RANBP9)

Protein Structure

UniProt Annotation

Function

May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol. Nucleus. Note==Predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells. {ECO:0000269PubMed:12147692, ECO:0000269PubMed:12361945, ECO:0000269PubMed:15381419}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 136 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	136 [view]
Protein-Protein	136 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008536	Ran GTPase binding
GO:0019899	enzyme binding

Biological Process

GO:0006461	protein complex assembly
GO:0007020	microtubule nucleation
GO:0007411	axon guidance
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005875	microtubule associated complex

Protein Structure and Domains

PDB ID

InterPro

IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR006594 LisH dimerisation motif
IPR006595 CTLH, C-terminal LisH motif
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR013144 CRA domain
IPR013720 LisH dimerisation motif, subgroup
IPR024964 CTLH/CRA C-terminal to LisH motif domain

PFAM

PF00622
PF08513
PF10607

PRINTS

PIRSF

SMART

SM00449
SM00667
SM00668
SM00757

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q96S59