Version 5.4
Mus musculus Protein: Treml2
Summary
InnateDB Protein IDBP-625365.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Treml2
Protein Name triggering receptor expressed on myeloid cells-like 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000128215
InnateDB Gene IDBG-189835 (Treml2)
Protein Structure
UniProt Annotation
Function Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in B-lymphocytes and macrophages. Detected in spleen, lymph nodes, blood, bone marrow and cells from the peritoneal cavity (at protein level). {ECO:0000269PubMed:16670310}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005515 protein binding
Biological Process
GO:0042110 T cell activation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2147038
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2LA85
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 328833
UniGene Mm.329104
RefSeq NP_001028577
MGI ID
MGI Symbol Treml2
OMIM
CCDS CCDS37646
HPRD
IMGT
EMBL DQ087184 DQ341272
GenPept ABA38680 ABC68265

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca