Version 5.4
Mus musculus Protein: Prr5l
Summary
InnateDB Protein IDBP-625457.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prr5l
Protein Name proline rich 5 like
Synonyms 2600010E01Rik; 4833411O04Rik; Protor-2; Protor2;
Species Mus musculus
Ensembl Protein ENSMUSP00000127530
InnateDB Gene IDBG-193288 (Prr5l)
Protein Structure
UniProt Annotation
Function Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. {ECO:0000269PubMed:22609986}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0009968 negative regulation of signal transduction
GO:0010762 regulation of fibroblast migration
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031929 TOR signaling
GO:0038203 TORC2 signaling
Cellular Component
GO:0005739 mitochondrion
GO:0031932 TORC2 complex
Protein Structure and Domains
PDB ID MGI:1919696
InterPro IPR013745 HbrB-like
PFAM PF08539
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AVJ5
PhosphoSite PhosphoSite-A2AVJ5
TrEMBL B0R106
UniProt Splice Variant
Entrez Gene 72446
UniGene Mm.474708
RefSeq NP_001104319
MGI ID
MGI Symbol Prr5l
OMIM
CCDS CCDS38186
HPRD
IMGT
EMBL AK011178 AK145981 AL929534 AL929571 BC048394 BC172132
GenPept AAH48394 AAI72132 BAC25324 BAE26803 CAM19333 CAM20506

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca