Version 5.4
Mus musculus Protein: Sco2
Summary
InnateDB Protein IDBP-625691.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sco2
Protein Name SCO cytochrome oxidase deficient homolog 2 (yeast)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000131943
InnateDB Gene IDBG-606426 (Sco2)
Protein Structure
UniProt Annotation
Function Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2). {ECO:0000250}.
Subcellular Localization Mitochondrion {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in retina, retinal pigment epithelium, and sclera. {ECO:0000269PubMed:23643385}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
Biological Process
GO:0001654 eye development
GO:0001701 in utero embryonic development
GO:0003012 muscle system process
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0008535 respiratory chain complex IV assembly
GO:0014823 response to activity
GO:0022904 respiratory electron transport chain
GO:0055070 copper ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0030016 myofibril
Protein Structure and Domains
PDB ID MGI:3818630
InterPro IPR003782 Copper chaperone SCO1/SenC
IPR012336 Thioredoxin-like fold
IPR017276 Synthesis of cytochrome c oxidase, Sco1/Sco2
PFAM PF02630
PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF PIRSF037736
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VCL2
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 100126824
UniGene
RefSeq NP_001104758
MGI ID
MGI Symbol Sco2
OMIM
CCDS CCDS49701
HPRD
IMGT
EMBL BC019554
GenPept AAH19554

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca