InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glo1

Summary

InnateDB Protein

IDBP-625705.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glo1

Protein Name

glyoxalase 1

Synonyms

0610009E22Rik; 1110008E19Rik; 2510049H23Rik; AW550643; Glo-1; Glo-1r; Glo-1s; Glo1-r; Glo1-s; GLY1; Qglo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000126586

InnateDB Gene

IDBG-161603 (Glo1)

Protein Structure

UniProt Annotation

Function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis. {ECO:0000269PubMed:18695250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004462	lactoylglutathione lyase activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006749	glutathione metabolic process
GO:0009438	methylglyoxal metabolic process
GO:0030316	osteoclast differentiation
GO:0043066	negative regulation of apoptotic process

Cellular Component

Protein Structure and Domains

PDB ID

MGI:95742

InterPro

IPR004360 Glyoxalase/fosfomycin resistance/dioxygenase domain
IPR004361 Glyoxalase I
IPR029068 Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase

PFAM

PF00903

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CPU0

PhosphoSite