InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dnahc8

Summary

InnateDB Protein

IDBP-625730.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnahc8

Protein Name

dynein, axonemal, heavy chain 8

Synonyms

ATPase; Dnahc8; Hst6.7b; P1-Loop;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127878

InnateDB Gene

IDBG-161654 (Dnahc8)

Protein Structure

UniProt Annotation

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. {ECO:0000269PubMed:10602986, ECO:0000269PubMed:12297094}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}.Isoform 1: Cell projection, cilium, flagellum. Cytoplasm. Note=Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. Location determined using antibody against peptide common to isoform 1 and isoform 2.Isoform 2: Cell projection, cilium, flagellum. Cytoplasm. Note=Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. Location determined using antibody against peptide common to isoform 1 and isoform 2.

Disease Associations

Tissue Specificity

Isoform 1 and/or isoform 2 are expressed in spermatocytes and mature sperm (at protein level). Testis- specific. Accumulates exclusively in mid to late spermatocytes. {ECO:0000269PubMed:10602986, ECO:0000269PubMed:12297094, ECO:0000269PubMed:16054618}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0007018	microtubule-based movement
GO:0008150	biological_process

Cellular Component

GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0030286	dynein complex
GO:0097228	sperm principal piece

Protein Structure and Domains

PDB ID

MGI:107714

InterPro

IPR003593 AAA+ ATPase domain
IPR004273 Dynein heavy chain domain
IPR011704 ATPase, dynein-related, AAA domain
IPR013594 Dynein heavy chain, domain-1
IPR013602 Dynein heavy chain, domain-2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF03028
PF07728
PF08385
PF08393

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91XQ0