Version 5.4
Mus musculus Protein: Tgfb1
Summary
InnateDB Protein IDBP-625989.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tgfb1
Protein Name transforming growth factor, beta 1
Synonyms TGF-beta1; Tgfb; Tgfb-1; TGFbeta1;
Species Mus musculus
Ensembl Protein ENSMUSP00000130413
InnateDB Gene IDBG-158292 (Tgfb1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 10 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001501 skeletal system development
GO:0001775 cell activation
GO:0002028 regulation of sodium ion transport
GO:0002513 tolerance induction to self antigen
GO:0006468 protein phosphorylation
GO:0006874 cellular calcium ion homeostasis
GO:0006952 defense response
GO:0006954 inflammatory response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007492 endoderm development
GO:0007519 skeletal muscle tissue development
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008354 germ cell migration
GO:0009887 organ morphogenesis
GO:0010628 positive regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016202 regulation of striated muscle tissue development
GO:0030217 T cell differentiation
GO:0030279 negative regulation of ossification
GO:0030879 mammary gland development
GO:0031065 positive regulation of histone deacetylation
GO:0032943 mononuclear cell proliferation
GO:0035066 positive regulation of histone acetylation
GO:0042110 T cell activation
GO:0042127 regulation of cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042306 regulation of protein import into nucleus
GO:0042482 positive regulation of odontogenesis
GO:0043011 myeloid dendritic cell differentiation
GO:0043029 T cell homeostasis
GO:0045066 regulatory T cell differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048535 lymph node development
GO:0050868 negative regulation of T cell activation
GO:0051098 regulation of binding
GO:0051101 regulation of DNA binding
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0060744 mammary gland branching involved in thelarche
GO:0060751 branch elongation involved in mammary gland duct branching
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0061035 regulation of cartilage development
GO:0070306 lens fiber cell differentiation
GO:0071158 positive regulation of cell cycle arrest
GO:0071363 cellular response to growth factor stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:1900182 positive regulation of protein localization to nucleus
GO:2000249 regulation of actin cytoskeleton reorganization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID MGI:98725
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9Q6I6
UniProt Splice Variant
Entrez Gene 21803
UniGene
RefSeq
MGI ID
MGI Symbol Tgfb1
OMIM
CCDS
HPRD
IMGT
EMBL AC162614
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca