InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lck

Summary

InnateDB Protein

IDBP-626013.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lck

Protein Name

lymphocyte protein tyrosine kinase

Synonyms

Hck-3; Lsk; Lskt; p56; p56Lck;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000125777

InnateDB Gene

IDBG-191117 (Lck)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 103 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	103 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0003823	antigen binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding
GO:0042609	CD4 receptor binding
GO:0042610	CD8 receptor binding
GO:0042802	identical protein binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0051117	ATPase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006882	cellular zinc ion homeostasis
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007166	cell surface receptor signaling pathway
GO:0007568	aging
GO:0009612	response to mechanical stimulus
GO:0010043	response to zinc ion
GO:0010628	positive regulation of gene expression
GO:0016311	dephosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030217	T cell differentiation
GO:0042493	response to drug
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042542	response to hydrogen peroxide
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0046777	protein autophosphorylation
GO:0050853	B cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051209	release of sequestered calcium ion into cytosol
GO:0070474	positive regulation of uterine smooth muscle contraction
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0000242	pericentriolar material
GO:0001772	immunological synapse
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0030139	endocytic vesicle
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:96756

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM