InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nin

Summary

InnateDB Protein

IDBP-626016.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nin

Protein Name

ninein

Synonyms

3110068G20Rik; AI385615; AU024711; mKIAA1565;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129648

InnateDB Gene

IDBG-145359 (Nin)

Protein Structure

UniProt Annotation

Function

Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppressed release of microtubules. {ECO:0000269PubMed:10934040}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:8834802}. Note=Component of the core centrosome. Arranged in a tubular conformation with an open and a closed end within the centrosome. In the mother centrosome, it localizes at both ends of the centrosome tube, including the site of centrosome duplication, while in the daughter centrosome it is present only at the closed end. Requires PCM1 for centrosome localization.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in spleen, bone marrow and skin. Weakly expressed in liver and small intestine. Expressed in brain. {ECO:0000269PubMed:8834802}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019900	kinase binding

Biological Process

GO:0034454	microtubule anchoring at centrosome
GO:0090222	centrosome-templated microtubule nucleation

Cellular Component

GO:0000922	spindle pole
GO:0005813	centrosome
GO:0005814	centriole
GO:0005874	microtubule

Protein Structure and Domains

PDB ID

MGI:105108

InterPro

IPR002048 EF-hand domain

PFAM

PF00036
PF13202
PF13405

PRINTS

PIRSF

SMART

SM00054

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61043

PhosphoSite

PhosphoSite-Q61043

TrEMBL

UniProt Splice Variant

Entrez Gene

18080

UniGene

Mm.402700

RefSeq

NP_001273009

MGI ID

MGI Symbol

Nin

OMIM

CCDS

CCDS36469

HPRD

IMGT

EMBL

AC112146 AC116574 AK129394 U40342

GenPept

AAA83234 BAC98204