InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Alx1

Summary

InnateDB Protein

IDBP-626113.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Alx1

Protein Name

ALX homeobox 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000129230

InnateDB Gene

IDBG-188383 (Alx1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that acts at a palindromic recognition sequence to enhance the activity of the SV40 and TK promoters. May play a role in chondrocyte differentiation and may also influence cervix development (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000255PROSITE-ProRule:PRU00138, ECO:0000269PubMed:12929931}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001843	neural tube closure
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0014031	mesenchymal cell development
GO:0030326	embryonic limb morphogenesis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048704	embryonic skeletal system morphogenesis
GO:0060021	palate development