InnateDB Protein
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IDBP-626141.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Slc38a3
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Protein Name
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solute carrier family 38, member 3
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Synonyms
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0610012J02Rik; D9Ucla2; mNAT; Nat1; Slc38-3; Sn1; Snat3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000130414
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InnateDB Gene
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IDBG-198073 (Slc38a3)
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Protein Structure
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Function |
Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission. {ECO:0000250UniProtKB:Q9JHZ9, ECO:0000269PubMed:10716701}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:10716701}; Multi-pass membrane protein {ECO:0000269PubMed:10716701}.
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Disease Associations |
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Tissue Specificity |
Expressed predominantly in liver, moderately expressed in kidney and brain, and barely detectable in heart and muscle. Within liver, expressed in hepatocytes. Not detected in testis. {ECO:0000269PubMed:10716701}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005290
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L-histidine transmembrane transporter activity
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GO:0015180
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L-alanine transmembrane transporter activity
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GO:0015182
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L-asparagine transmembrane transporter activity
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GO:0015186
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L-glutamine transmembrane transporter activity
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GO:0015293
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symporter activity
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GO:0015297
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antiporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1923507
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InterPro |
IPR013057
Amino acid transporter, transmembrane
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PFAM |
PF01490
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DCP2
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PhosphoSite |
PhosphoSite-Q9DCP2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
76257
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UniGene |
Mm.488163
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RefSeq |
XP_006511909
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MGI ID |
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MGI Symbol |
Slc38a3
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OMIM |
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CCDS |
CCDS23503
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HPRD |
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IMGT |
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EMBL |
AF159856
AK002607
AK035155
BC054846
BC055339
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GenPept |
AAF61849
AAH54846
AAH55339
BAB22226
BAC28963
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