Version 5.4
Homo sapiens Protein: SSX1
Summary
InnateDB Protein IDBP-62615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSX1
Protein Name synovial sarcoma, X breakpoint 1
Synonyms CT5.1; SSRC;
Species Homo sapiens
Ensembl Protein ENSP00000366118
InnateDB Gene IDBG-62613 (SSX1)
Protein Structure
UniProt Annotation
Function Could act as a modulator of transcription.
Subcellular Localization
Disease Associations Note=A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
Tissue Specificity Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR001909 Krueppel-associated box
IPR003655 Krueppel-associated box-related
IPR019041 SSXRD motif
PFAM PF01352
PF09514
PRINTS
PIRSF
SMART SM00349
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q16384
PhosphoSite PhosphoSite-Q16384
TrEMBL
UniProt Splice Variant
Entrez Gene 6756
UniGene Hs.434142
RefSeq NP_005626
HUGO HGNC:11335
OMIM 312820
CCDS CCDS14290
HPRD 02428
IMGT
EMBL AL683817 BC001003 BC125151 BC128611 BC133693 BC150487 S79325 X86174
GenPept AAB35378 AAH01003 AAI25152 AAI28612 AAI33694 AAI50488 CAA60110 CAI41141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca