Version 5.4
Mus musculus Protein: Scrt1
Summary
InnateDB Protein IDBP-626287.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Scrt1
Protein Name scratch homolog 1, zinc finger protein (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000131152
InnateDB Gene IDBG-155553 (Scrt1)
Protein Structure
UniProt Annotation
Function Transcriptional repressor that binds E-box motif CAGGTG (By similarity). Appears to function downstream of proneural bHLH proteins in promoting neural differentiation. {ECO:0000250, ECO:0000269PubMed:11687288}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:2001222 regulation of neuron migration
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2176606
InterPro IPR007087 Zinc finger, C2H2
IPR015880 Zinc finger, C2H2-like
PFAM PF00096
PRINTS
PIRSF
SMART SM00355
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99M85
PhosphoSite PhosphoSite-Q99M85
TrEMBL
UniProt Splice Variant
Entrez Gene 170729
UniGene Mm.218747
RefSeq
MGI ID
MGI Symbol Scrt1
OMIM
CCDS CCDS37123
HPRD
IMGT
EMBL AY014997 BC057562
GenPept AAH57562 AAK01468

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca