InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brcc3

Summary

InnateDB Protein

IDBP-626291.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brcc3

Protein Name

BRCA1/BRCA2-containing complex, subunit 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000127772

InnateDB Gene

IDBG-157387 (Brcc3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 35 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	35 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0030234	enzyme regulator activity
GO:0031593	polyubiquitin binding

Biological Process

GO:0006302	double-strand break repair
GO:0006508	proteolysis
GO:0010165	response to X-ray
GO:0031572	G2 DNA damage checkpoint
GO:0045739	positive regulation of DNA repair
GO:0050790	regulation of catalytic activity
GO:0070537	histone H2A K63-linked deubiquitination

Cellular Component

GO:0000152	nuclear ubiquitin ligase complex
GO:0070531	BRCA1-A complex
GO:0070552	BRISC complex

Protein Structure and Domains

PDB ID

MGI:2389572

InterPro

IPR000555 JAB1/MPN/MOV34 metalloenzyme domain

PFAM

PF01398

PRINTS

PIRSF

SMART

SM00232

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

E9Q0P6

UniProt Splice Variant

Entrez Gene

210766

UniGene

Mm.416059

RefSeq

MGI ID

MGI Symbol

Brcc3

OMIM

CCDS

HPRD

IMGT

EMBL

AL671860

GenPept