Version 5.4
Mus musculus Protein: Gpr81
Summary
InnateDB Protein IDBP-626313.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gpr81
Protein Name G protein-coupled receptor 81
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000129280
InnateDB Gene IDBG-200080 (Gpr81)
Protein Structure
UniProt Annotation
Function Acts as a receptor for L-lactate and mediates its anti- lipolytic effect through a G(i)-protein-mediated pathway. {ECO:0000269PubMed:18174606, ECO:0000269PubMed:19047060}.
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Highly expressed in subcutaneous fat and omental fat and detectable in lower levels in brain and many other tissues. High levels detected in epididymal and subcutaneous fat with slightly lower in omental fat, low levels are detected in the brain, skeletal muscle, kidney, liver and the pancreas (at protein level). {ECO:0000269PubMed:18174606, ECO:0000269PubMed:19047060}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
Biological Process
GO:0007186 G-protein coupled receptor signaling pathway
GO:0032355 response to estradiol
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2441671
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
PFAM PF00001
PRINTS PR00237
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C131
PhosphoSite PhosphoSite-Q8C131
TrEMBL E9PZR8
UniProt Splice Variant
Entrez Gene 243270
UniGene Mm.416403
RefSeq NP_780729
MGI ID
MGI Symbol Hcar1
OMIM
CCDS CCDS19669
HPRD
IMGT
EMBL AC122753 AC129582 AK029064 BC141305 EU809460
GenPept AAI41306 ACJ03846 BAC26273

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca