InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Phlda1

Summary

InnateDB Protein

IDBP-626381.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Phlda1

Protein Name

pleckstrin homology-like domain, family A, member 1

Synonyms

DT1P1B11; Tdag; TDAG51;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000132815

InnateDB Gene

IDBG-190194 (Phlda1)

Protein Structure

UniProt Annotation

Function

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR- induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation. {ECO:0000269PubMed:15037619, ECO:0000269PubMed:8673705}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle membrane. Nucleus, nucleolus {ECO:0000250}. Note=Colocalizes with intracellular vesicles.

Disease Associations

Tissue Specificity

Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema. {ECO:0000269PubMed:10428057, ECO:0000269PubMed:10594239, ECO:0000269PubMed:12738777}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007010	cytoskeleton organization
GO:0021879	forebrain neuron differentiation
GO:0043065	positive regulation of apoptotic process
GO:0045210	FasL biosynthetic process