InnateDB Protein
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IDBP-626432.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Wdfy3
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Protein Name
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WD repeat and FYVE domain containing 3
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Synonyms
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2610509D04Rik; ALFY; AW319683; B930017C24; Bchs; BWF1; D5Ertd66e; Ggtb3; mKIAA0993; ZFYVE25;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000134541
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InnateDB Gene
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IDBG-183982 (Wdfy3)
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Protein Structure
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Function |
Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Membrane {ECO:0000269PubMed:15342963}; Peripheral membrane protein {ECO:0000269PubMed:15342963}; Cytoplasmic side {ECO:0000269PubMed:15342963}. Note=Colocalizes with autophagic structures in starved cells. Shuttles between nucleus and cytoplasm; translocation from the nucleus to cytoplasmic polyubiquitin-containing bodies upon cellular stress is dependent on SQSTM1 (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Detected in liver, kidney and testis. {ECO:0000269PubMed:15342963}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
16 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1096875
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InterPro |
IPR016024
Armadillo-type fold
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6VNB8
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PhosphoSite |
PhosphoSite-Q6VNB8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
72145
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UniGene |
Mm.414719
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RefSeq |
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MGI ID |
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MGI Symbol |
Wdfy3
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK047077
AY336569
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GenPept |
AAQ84516
BAC32952
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