InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Syn2

Summary

InnateDB Protein

IDBP-626434.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Syn2

Protein Name

synapsin II

Synonyms

2900074L19Rik; AI836018; AI841723;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000133121

InnateDB Gene

IDBG-179119 (Syn2)

Protein Structure

UniProt Annotation

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons. {ECO:0000269PubMed:22673524}.

Subcellular Localization

Cell junction, synapse.

Disease Associations

Tissue Specificity

Expressed exclusively in neuronal cells. Isoform IIb is enriched in sympathetic cervical ganglion. {ECO:0000269PubMed:8034599}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005524	ATP binding
GO:0046983	protein dimerization activity

Biological Process

GO:0007269	neurotransmitter secretion
GO:0008152	metabolic process

Cellular Component

GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0045202	synapse

Protein Structure and Domains

PDB ID

MGI:103020

InterPro

IPR001359 Synapsin
IPR013651 ATP-grasp fold, RimK-type
IPR016185 Pre-ATP-grasp domain
IPR019736 Synapsin, phosphorylation site
IPR020897 Synapsin, pre-ATP-grasp domain
IPR020898 Synapsin, ATP-binding domain

PFAM

PF08443
PF10581
PF02078
PF02750

PRINTS

PR01368

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q64332