InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cul3

Summary

InnateDB Protein

IDBP-626486.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cul3

Protein Name

cullin 3

Synonyms

AI467304; AW146203; mKIAA0617;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000131891

InnateDB Gene

IDBG-173179 (Cul3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 1038 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1038 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030332	cyclin binding
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0001701	in utero embryonic development
GO:0001831	trophectodermal cellular morphogenesis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007369	gastrulation
GO:0008054	cyclin catabolic process
GO:0016055	Wnt signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0031461	cullin-RING ubiquitin ligase complex

Protein Structure and Domains

PDB ID

MGI:1347360

InterPro

IPR001373 Cullin, N-terminal
IPR016158 Cullin homology
IPR016159 Cullin repeat-like-containing domain
IPR019559 Cullin protein, neddylation domain

PFAM

PF00888
PF10557

PRINTS

PIRSF

SMART

SM00182
SM00884

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9CTE0

UniProt Splice Variant

Entrez Gene

26554

UniGene

Mm.456495

RefSeq

MGI ID

MGI Symbol

Cul3

OMIM

CCDS

HPRD

IMGT

EMBL

AC161416 AC166157 AK003885

GenPept

BAB23057