InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dag1

Summary

InnateDB Protein

IDBP-626499.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dag1

Protein Name

dystroglycan 1

Synonyms

D9Wsu13e; DG; Dp427; Dp71;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000130626

InnateDB Gene

IDBG-199494 (Dag1)

Protein Structure

UniProt Annotation

Function

The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also receptor for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity). {ECO:0000250}.

Subcellular Localization

Alpha-dystroglycan: Secreted, extracellular space {ECO:0000250}.Beta-dystroglycan: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals. In peripheral nerves, localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann-cell microvilli.

Disease Associations

Tissue Specificity

Expressed in a variety of tissues. In brain, expressed in the hippocampal formation, the olfactory bulb, the cerebellum and the thalamus. In the peripheral nerve system, expressed in Schwann cells. {ECO:0000269PubMed:12843252, ECO:0000269PubMed:7833916, ECO:0000269PubMed:9175728}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0003779	actin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008307	structural constituent of muscle
GO:0015631	tubulin binding
GO:0017166	vinculin binding
GO:0032403	protein complex binding
GO:0042169	SH2 domain binding
GO:0051393	alpha-actinin binding

Biological Process

GO:0002011	morphogenesis of an epithelial sheet
GO:0006509	membrane protein ectodomain proteolysis
GO:0006607	NLS-bearing protein import into nucleus
GO:0007016	cytoskeletal anchoring at plasma membrane
GO:0014044	Schwann cell development
GO:0016340	calcium-dependent cell-matrix adhesion
GO:0019048	modulation by virus of host morphology or physiology
GO:0021682	nerve maturation
GO:0022011	myelination in peripheral nervous system
GO:0030336	negative regulation of cell migration
GO:0034453	microtubule anchoring
GO:0043409	negative regulation of MAPK cascade
GO:0043434	response to peptide hormone
GO:0051898	negative regulation of protein kinase B signaling
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060445	branching involved in salivary gland morphogenesis
GO:0071679	commissural neuron axon guidance
GO:0071711	basement membrane organization

Cellular Component

GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005913	cell-cell adherens junction
GO:0005925	focal adhesion
GO:0009279	cell outer membrane
GO:0016010	dystrophin-associated glycoprotein complex
GO:0016011	dystroglycan complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0033268	node of Ranvier
GO:0042383	sarcolemma
GO:0043034	costamere
GO:0045121	membrane raft
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome
GO:0070938	contractile ring