Version 5.4
Mus musculus Protein: Fxyd3
Summary
InnateDB Protein IDBP-626571.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fxyd3
Protein Name FXYD domain-containing ion transport regulator 3
Synonyms Mat8;
Species Mus musculus
Ensembl Protein ENSMUSP00000130245
InnateDB Gene IDBG-172317 (Fxyd3)
Protein Structure
UniProt Annotation
Function Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in a subset of murine breast tumors.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0051117 ATPase binding
Biological Process
GO:0006811 ion transport
GO:0034220 ion transmembrane transport
GO:0050790 regulation of catalytic activity
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:107497
InterPro IPR000272 Ion-transport regulator, FXYD motif
PFAM PF02038
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61835
PhosphoSite PhosphoSite-
TrEMBL Q3TLM3
UniProt Splice Variant
Entrez Gene 17178
UniGene Mm.263847
RefSeq NP_032583
MGI ID
MGI Symbol Fxyd3
OMIM
CCDS CCDS21125
HPRD
IMGT
EMBL AC158993 AK145206 AK166426 BC002039 BC056223 CH466593 X93038
GenPept AAH02039 AAH56223 BAE26297 BAE38769 CAA63606 EDL23956

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca