InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx6

Summary

InnateDB Protein

IDBP-626656.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx6

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 6

Synonyms

1110001P04Rik; E230023J21Rik; HLR2; mRCK/P54; p54; rck;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128421

InnateDB Gene

IDBG-157702 (Ddx6)

Protein Structure

UniProt Annotation

Function

In the process of mRNA degradation, may play a role in mRNA decapping.

Subcellular Localization

Cytoplasm, P-body {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0033962	cytoplasmic mRNA processing body assembly

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0016442	RISC complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:104976

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54823